FORMULATION AND EVALUATION OF FAMOTIDINE SUBLINGUAL TABLETS

Formulation and Evaluation of New Glimepiride Sublingual Tablets

Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glime...

Formulation and Invitro - Evaluation of Gastro - Retentive Superporous Hydrogel Tablets of Famotidine

Formulation and in Vitro - in Vivo Evaluation of Bilayer Floating- Bioadhesive Famotidine Tablets

Bilayer floating-bioadhesive drug delivery systems exhibiting a unique combination of floatation and bioadhesion to prolong gastric residence time were developed. Hydroxypropyl methylcellulose and sodium bicarbonate were added such that when immersed in 0.1N HCl, the tablet expands and rises to the surface and famotidine is gradually released without interference from gas bubbles. Effect of dif...

Formulation and in Vitro Evaluation of Famotidine Floating Tablets by Lipid Solid Dispersion Spray Drying Technique

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friabi...

Formulation, Optimization and in Vitro Evaluation of Rapid Disintegrating and Mucoadhesive Sublingual Tablets of Lorazepam

Lorazepam a benzodiazepine drug is used as an antianxiety, sedative, hypnotic, and anticonvulsant drug. Bypassing the enterohepatic recirculation and first-pass metabolism of lorazepam by sublingual delivery of this drug may accelerate the onset of its action. The objective of this study was the formulation, optimization and in vitro characterization of mucoadhesive sublingual tablets of loraze...